Summary
Dietary interventions historically have not been effective in the treatment of multiple sclerosis (MS). Here researchers show that periodic 3 day cycles of a fasting mimicking diet (FMD) are effective in improving demyelination (damage to the protective covering around nerve fibers in the brain, eyes, and spinal cord) and symptoms in an experimental autoimmune brain inflammation (EAE) model in mice.
A fast mimicking diet often consists of fasting fuels such as nuts, olives, or pickles, which don't break your fast when eaten in limited quantities.
The FMD reduced clinical severity in all mice, and completely reversed symptoms in 20% of the animals. Moreover, the FMD promoted growth and regeneration in the cells that generate the myelin sheath. We also report preliminary data suggesting that a FMD or a chronic ketogenic diet are safe, feasible and potentially effective in the treatment of relapsing remitting multiple sclerosis (RRMS) patients (NCT01538355).
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