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Influence of Short-Term Repeated Fasting on the Longevity of Female (NZB x NZW)F1 Mice

Sogawa, H; Kubo, C

May 18, 2000

Mechanisms of Ageing and Development, vol. 115, no. 1–2, May 2000, pp. 61–71. PubMed,

Caloric restriction in rodents is well known to retard the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many age-associated diseases. However, little is known about the influence of short-term repeated fasting on longevity. In this study, female (NZB x NZW)F1 mice were used to test the physiological effect of short-term repeated fasting (4 consecutive days, every 2 weeks). The results showed that fasting mice survived significantly longer than the full-fed mice, in spite of the fasting group having a heavier body weight than the control group. Mean survival times for fasting and control mice were 64.0+/-15.3 and 47.9+/-9.4 weeks, respectively. Short-term repeated fasting manipulation was also effective on the prolongation of life-span in autoimmune-prone mice.

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Longevity, Aging, Intermittent Fasting

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