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Anti-Obesity Effects of Starter Fermented Kimchi on 3T3-L1 Adipocytes

Lee, KH; Song, JL; Park, ES; Ju J; Kim HY; Park, KY

Dec 1, 2015

Lee, Kyung-Hee, et al. “Anti-Obesity Effects of Starter Fermented Kimchi on 3T3-L1 Adipocytes.” Preventive Nutrition and Food Science, vol. 20, no. 4, Dec. 2015, pp. 298–302. PubMed,

The anti-obesity effects of starter (Leuconostoc mesenteroides+Lactobacillus plantarum) fermented kimchi on 3T3-L1 adipocyte were studied using naturally fermented kimchi (NK), a functional kimchi (FK, NK supplemented with green tea), and FK supplemented with added starters (FKS). Oil red O staining and cellular levels of triglyceride (TG) and glycerol were used to evaluate the in vitro anti-obesity effects of these kimchis in 3T3-L1 cells. The expressions of adipogenesis/lipogenesis-related genes of peroxisome proliferator-active receptor (PPAR)-γ, CCAAT/enhance-binding protein (C/EBP)-α, and fatty acid synthase (FAS) were determined by RT-PCR. Kimchis, especially FKS, markedly decreased TG levels and increased levels of intracellular glycerol and lipid lipolysis. In addition, FKS also reduced the mRNA levels of PPAR-γ, C/EBP-α, and FAS, which are related to adipogenesis/lipogenesis in 3T3-L1 cells. These results suggest the anti-obesity effects of FKS were to due to enhanced lipolysis and reduced adipogenesis/lipogenesis in 3T3-L1 adipocytes.

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Triglycerides, Obesity, Nutrition

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